Age-Related Changes in Doxorubicin-Induced Oxidative Damage: Protective and Pretreatment Effects of Short-Term Aerobic Exercise
ABSTRACT Background and Objective: Doxorubicin (DOX) is an effective anticancer drug.It has been shown that a short-term exercise performed prior to DOX-treatment has no effect on cardiotoxicity in young rats.In the present study, old and young rats were evaluated to determine the protective effects of pre-treatment with short-term exercise on DOX-